top of page


LGD-4033 (often also called as Ligandrol) is a oral, nonsteroidal and potent selective androgen receptor modulator (SARM). It was developed to increase anabolic activity and reduce muscle wasting in people with severe diseases associated with catabolic conditions and critical loss of muscle mass. In clinical trials, LGD-4033 has shown significant anabolic activity in muscles and antiresorptive and anabolic activity in bones, along with a high selectivity to act in these tissues (where appropriate and desirable) and minimally in other tissues and organs, where undesirable. 


The results of clinical trials conducted by the Endocrinology section of the Boston Medical Center also indicate that LGD-4033 can significantly help in increasing muscle mass and muscle strength in severe diseases associated with muscle wasting and without significant side effects (which may be caused by treatment of these diseases with androgenic drugs – steroids). Similarly, another study conducted in January 2013 confirmed that Ligandrol can help increase muscle mass in muscle tissue and its use was well tolerated by test subjects.


So when we summarize it: LGD-4033 (Ligandrol) has a very strong anabolic activity that makes it possible to help bodybuilders and athletes achieve muscle gains fully comparable to those that can be achieved using the most effective “bulking” anabolic steroids, but without most of the dangerous and unpleasant side effects that such steroids cause. Thus, Ligandol is a great full-fledged alternative for them to the most effective anabolic steroids aimed at muscle gains, while being much safer, less harmful and less risky than using steroids.


The World Anti-Doping Agency (WADA) banned all SARMs (including Ligandrol) as early as 2008. Since then, there have been several notable cases where professional athletes have been positive tested for LGD-4033:


    • Significant and selective anabolic activity in muscles and bones, without strong androgenic undesirable effects and negative effects in other organs
    • Promising candidate for the treatment of serious diseases associated with muscle wasting
    • Promising candidate for the treatment of osteoporosis and fractures
    • Very effectively helps build lean muscle mass
    • Has strong anti-catabolic effects and ability to maintain muscle mass even with reduced caloric intake
    • Increases bone density and helps prevent bone loss


    • SARM LGD-4033 is highly selective and primarily aimed at acting in muscles and bones. Due to this selectivity, unlike anabolic steroids, it does not cause strong androgenic side effects and negative effects on other organs
    • LGD-4033 has anabolic activity fully comparable to anabolic steroids, is able to help achieve muscle mass growth in the similar results, but without many of the negative effects and health risks that arise from the use of anabolic steroids:
        • LGD-4033 does not interact with enzymes of CYP19 aromatase or 5α-reductase (LGD-4033 does not convert on Estrogens or Dihydrotestosterone (DHT))
        • LGD-4033 does not cause Gynecomastia (abnormal development of mammary glands in men causing breast enlargement)
        • LGD-4033 does not cause significant retention of water and salts in the body
        • LGD-4033 does not cause increased Cortisol and Estrogen production
        • LGD-4033 does not present a heavy load and damage to the Liver
        • LGD-4033 does not cause prostate enlargement
        • LGD-4033 does not cause kidney disease
        • LGD-4033 does not cause acne and oily skin
        • LGD-4033 does not cause hair loss and baldness
        • LGD-4033 does not cause swollen face
        • LGD-4033 does not cause excess facial or body hair (hirsutism)
        • LGD-4033 does not cause sudden changes in mood and behavior
        • LGD-4033 does not cause irritability, nervousness, depression, restlessness
        • LGD-4033 does not cause aggression, explosiveness and psychological problems
        • LGD-4033 is highly effective when administered orally (no injections required)


    • LGD-4033 suppresses the production and reduces the levels of natural Testosterone in the body
    • After discontinuation, therapy is required in many cases to restore the natural production of testosterone
    • LGD-4033 may increase the risk of heart attack and stroke (in the elderly)
    • LGD-4033 may have adverse effects on blood lipid levels
    • LGD-4033 may decrease libido and potency


What is LGD-4033 (Ligandrol)?

LGD-4033 (Ligandrol) is a oral, nonsteroidal and potent selective androgen receptor modulator (SARM), expected to deliver the therapeutic benefits of testosterone with improved safety, tolerability and patient acceptance due to tissue-selective mechanisms of action and oral routes of administration.

What does LGD-4033 do?

LGD-4033 binds to androgen receptor with high affinity (Ki of ∼1 nM) and selectivity in muscle and bone tissues. It has strong anabolic effects on building new muscle mass, and strong anti-catabolic effects and ability to maintain muscle mass even with reduced caloric intake.

What is Ligandrol used for?

LGD-4033 is a selective androgen receptor modulator (SARM), that is currently being investigated as a pharmaceutical treatment for muscle wasting and weakness associated with aging.

Yes, the World Anti-Doping Agency (WADA) banned all SARMs including Ligandrol (LGD-4033) as early as 2008.

Is LGD-4033 Ligandrol use legal in USA?

Since LGD-4033 Ligandrol is still a investigational new compound, it has not yet been approved to be marketed for consumption by humans in the United States. However, it has been used experimentally by some in the bodybuilding community.

Does LGD-4033 Ligandrol lower testosterone?

LGD-4033 suppresses the production and reduces the levels of natural Testosterone in the body, but considerably less than some anabolic steroids. The effect on the reduction of testosterone production is also influenced by the size of the dose and the length of its use.

How safe is LGD 4033?



    bottom of page